Peptidic Termini Play a Significant Role in TCR Recognition

TCR Recognition Peptidic Termini Play a Significant Role in

Peptidic termini play a significant role in TCR recognition.

TCR recognition of class I MHC is dependent on the composition of the antigenic peptide and the MHC. Single amino acid substitutions in either the MHC or the peptide may dramatically alter recognition. While the major interactions between TCR and the peptide/MHC complex appear to be focused on the complementarity-determining region (CDR)3, it is also clear from the cocrystal structure of class ...

Behçet’s Disease: Do Natural Killer Cells Play a Significant Role?

Behçet's disease (BD) is a complex inflammatory disease, of unknown etiology. While disease pathogenesis remains unclear, a strong relationship between BD and HLA-B*51 has been established over the last 30 years. A number of theories exist regarding the cause of BD; however, few are able to account for the increased rates of HLA-B*51 positive individuals, particularly around the Mediterranean b...

Urolithiasis – do ureaplasmas play a role in etiology.

Background and Objective: Urinary tract infections (UTIs) caused by urease-producing organisms, including ureaplasmas may contribute to the formation of urolithiasis. We aimed to determine the frequency of U. parvum and U. urealyticum among urology hospital patients with urinary stones. Methods: The study group included 30 men with urolithiasis. Urine samples were examined routinely for bacte...

Core histone N-termini play an essential role in mitotic chromosome condensation.

We have studied the role of core histone tails in the assembly of mitotic chromosomes using Xenopus egg extracts. Incubation of sperm nuclei in the extracts led to the formation of mitotic chromosomes, a process we found to be correlated with phosphorylation of the N-terminal tail of histone H3 at Ser10. When the extracts were supplemented with H1-depleted oligosomes, they were not able to asse...